The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated leukocytes, where 5-lipoxygenase (5-LO) translocates to the nuclear envelope to assemble a functional complex with the integral nuclear membrane protein 5-LO-activating protein (FLAP). FLAP, a MAPEG family member, facilitates AA transfer to 5-LO for efficient conversion, and LT biosynthesis critically depends on FLAP. Here we show that the novel LT biosynthesis inhibitor BRP-187 prevents the 5-LO/FLAP interaction at the nuclear envelope of human leukocytes without blocking 5-LO nuclear redistribution. BRP-187 inhibited 5-LO product formation in human monocytes and polymorphonuclear leukocytes stimulated by lipopolysaccharide plus N-formyl-methionyl-le...
Leukotrienes are lipid inflammatory mediators that are implicated in asthma, COPD, arthritis, cardio...
Abstract: Leukotrienes (LT) are biosynthetic products derived from arachidonic acid. Investigational...
Resolution of acute inflammation is an active process coordinated by proresolving lipid mediators (S...
The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated leukocyte...
Background and Purpose Leukotrienes (LTs) are inflammatory mediators produced via the 5-lipoxygenase...
Background and Purpose: Lipid mediators (LM) play crucial roles in the complex inflammation process ...
Leukotrienes (LTs) are pro-inflammatory mediators linked to a variety of diseases including asthma, ...
BACKGROUND AND PURPOSE: Leukotrienes (LTs) are inflammatory mediators produced via the 5-lipoxygena...
5-Lipoxygenase (5-LO) catalyzes the first two steps in leukotriene (LT) biosynthesis. Because LTs pl...
Leukotrienes are potent inflammatory mediators synthesized from arachidonic acid (AA) predominately ...
Abstract5-Lipoxygenase-activating protein (FLAP) is an 18-kDa integral membrane protein which is ess...
Leukotrienes (LTs) and prostaglandin (PG)E-2, produced by 5-lipoxygenase (5-LO) and microsomal prost...
5-Lipoxygenase (5LO) is a key enzyme in biosynthesis of leukotrienes (LTs), lipid mediators of infla...
Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are s...
Leukotrienes are lipid inflammatory mediators that are implicated in asthma, COPD, arthritis, cardio...
Abstract: Leukotrienes (LT) are biosynthetic products derived from arachidonic acid. Investigational...
Resolution of acute inflammation is an active process coordinated by proresolving lipid mediators (S...
The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated leukocyte...
Background and Purpose Leukotrienes (LTs) are inflammatory mediators produced via the 5-lipoxygenase...
Background and Purpose: Lipid mediators (LM) play crucial roles in the complex inflammation process ...
Leukotrienes (LTs) are pro-inflammatory mediators linked to a variety of diseases including asthma, ...
BACKGROUND AND PURPOSE: Leukotrienes (LTs) are inflammatory mediators produced via the 5-lipoxygena...
5-Lipoxygenase (5-LO) catalyzes the first two steps in leukotriene (LT) biosynthesis. Because LTs pl...
Leukotrienes are potent inflammatory mediators synthesized from arachidonic acid (AA) predominately ...
Abstract5-Lipoxygenase-activating protein (FLAP) is an 18-kDa integral membrane protein which is ess...
Leukotrienes (LTs) and prostaglandin (PG)E-2, produced by 5-lipoxygenase (5-LO) and microsomal prost...
5-Lipoxygenase (5LO) is a key enzyme in biosynthesis of leukotrienes (LTs), lipid mediators of infla...
Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are s...
Leukotrienes are lipid inflammatory mediators that are implicated in asthma, COPD, arthritis, cardio...
Abstract: Leukotrienes (LT) are biosynthetic products derived from arachidonic acid. Investigational...
Resolution of acute inflammation is an active process coordinated by proresolving lipid mediators (S...