Add to ORKGAntimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to issues relating to toxicity, short biological half-life, and lack of efficacy against Gram-negative bacteria. However, the development of novel AMP-nanomedicines, i.e. AMPs entrapped in nanoparticles, has the potential to ameliorate these clinical problems. The authors investigated two novel nanomedicines based on AA139, an AMP currently in development for the treatment of multidrug-resistant Gram-negative infections. AA139 was entrapped in polymeric nanoparticles (PNP) or lipid-core micelles (MCL). The antimicrobial activity of AA139-PNP and AA139-MCL was determined in vitro The biodistribution and limiting doses of AA139-nanomedicines were...
Many infectious diseases are still prevalent in the world’s populations since no effective treatment...
Anti-microbial resistance is a growing problem that has impacted the world and brought about the beg...
Antimicrobial peptides (AMP) are molecules consisting of 12–100 amino acids synthesized by certain m...
Antimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to...
Microbial infections are still among the major public health concerns since several yeasts and fungi...
Introduction: Antibiotic-resistant bacteria kill 25,000 people every year in the EU. Patients subjec...
Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic...
Introduction: Resistance to traditional antibiotics is an increasingly serious problem. Antimicrobia...
The introduction of antibiotics has revolutionized the treatment and prevention of microbial infect...
Microbial infections are still among the major public health concerns since several yeasts and fungi...
With the dramatic rise in antibiotic resistance, including untreatable infections of multi-resistant...
Objectives The aim of this study was to examine how the concentrated delivery of less effective anti...
Antimicrobial peptides (AMPs) are a class of promising anti-infective molecules but their therapeut...
Despite the fact that we live in an era with unique and advanced technology for revealing underlying...
Today's human society, product of decades of progress in all fields of knowledge, would have been un...
Many infectious diseases are still prevalent in the world’s populations since no effective treatment...
Anti-microbial resistance is a growing problem that has impacted the world and brought about the beg...
Antimicrobial peptides (AMP) are molecules consisting of 12–100 amino acids synthesized by certain m...
Antimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to...
Microbial infections are still among the major public health concerns since several yeasts and fungi...
Introduction: Antibiotic-resistant bacteria kill 25,000 people every year in the EU. Patients subjec...
Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic...
Introduction: Resistance to traditional antibiotics is an increasingly serious problem. Antimicrobia...
The introduction of antibiotics has revolutionized the treatment and prevention of microbial infect...
Microbial infections are still among the major public health concerns since several yeasts and fungi...
With the dramatic rise in antibiotic resistance, including untreatable infections of multi-resistant...
Objectives The aim of this study was to examine how the concentrated delivery of less effective anti...
Antimicrobial peptides (AMPs) are a class of promising anti-infective molecules but their therapeut...
Despite the fact that we live in an era with unique and advanced technology for revealing underlying...
Today's human society, product of decades of progress in all fields of knowledge, would have been un...
Many infectious diseases are still prevalent in the world’s populations since no effective treatment...
Anti-microbial resistance is a growing problem that has impacted the world and brought about the beg...
Antimicrobial peptides (AMP) are molecules consisting of 12–100 amino acids synthesized by certain m...