Growth factors can steer the biological response to a biomaterial post implantation. Heparin is a growth factor binding molecule that can coordinate growth factor presentation to cells and therefore is able to regulate many biological processes. One way to functionalize biomaterials with heparin and growth factors is via a supramolecular approach. Here, we show a proof-of-concept study in which a supramolecular approach based on ureido-pyrimidinone (UPy) was used, which allows for modular functionalization. PCLdiUPy was functionalized with a UPy-modified heparin binding peptide (UPy-HBP) to facilitates binding of heparin, which in turn can bind vascular endothelial growth factor (VEGF) via its heparin binding domain. The adsorption of both ...
High concentrations of supplemented growth factors can cause oversaturation and adverse effects in i...
Heparin-based hydrogels are attractive for controlled growth factor delivery, due to the native abil...
<div><p>In a typical cell culture system, growth factors immobilized on the cell culture surfaces ca...
Growth factors can steer the biological response to a biomaterial post implantation. Heparin is a gr...
Cataloged from PDF version of article.Immobilization of growth factors in scaffolds is important for...
Immobilization of growth factors in scaffolds is important for controlling their dose and bioactivit...
Our aim was to synthesize a biomaterial that stimulates angiogenesis for tissue engineering applicat...
Albeit the roles of growth factors (e.g. VEGF) and their receptors in angiogenesis have been emphasi...
Vascular endothelial growth factor (VEGF) is known to activate proliferation, migration, and surviva...
Three-dimensional scaffolds have the capacity to serve as an architectural framework to guide and pr...
Numerous strategies have been proposed to decorate biomaterials with growth factors (GFs) for tissue...
Insufficient endothelialization of cardiovascular devices is a high-risk factor for implant failure....
Effective vascularization is crucial for almost any therapeutic tissue engineering concept. In this ...
High concentrations of supplemented growth factors can cause oversaturation and adverse effects in i...
Tissue regeneration into a three-dimensional scaffold requires the stimulation of blood vessel ingro...
High concentrations of supplemented growth factors can cause oversaturation and adverse effects in i...
Heparin-based hydrogels are attractive for controlled growth factor delivery, due to the native abil...
<div><p>In a typical cell culture system, growth factors immobilized on the cell culture surfaces ca...
Growth factors can steer the biological response to a biomaterial post implantation. Heparin is a gr...
Cataloged from PDF version of article.Immobilization of growth factors in scaffolds is important for...
Immobilization of growth factors in scaffolds is important for controlling their dose and bioactivit...
Our aim was to synthesize a biomaterial that stimulates angiogenesis for tissue engineering applicat...
Albeit the roles of growth factors (e.g. VEGF) and their receptors in angiogenesis have been emphasi...
Vascular endothelial growth factor (VEGF) is known to activate proliferation, migration, and surviva...
Three-dimensional scaffolds have the capacity to serve as an architectural framework to guide and pr...
Numerous strategies have been proposed to decorate biomaterials with growth factors (GFs) for tissue...
Insufficient endothelialization of cardiovascular devices is a high-risk factor for implant failure....
Effective vascularization is crucial for almost any therapeutic tissue engineering concept. In this ...
High concentrations of supplemented growth factors can cause oversaturation and adverse effects in i...
Tissue regeneration into a three-dimensional scaffold requires the stimulation of blood vessel ingro...
High concentrations of supplemented growth factors can cause oversaturation and adverse effects in i...
Heparin-based hydrogels are attractive for controlled growth factor delivery, due to the native abil...
<div><p>In a typical cell culture system, growth factors immobilized on the cell culture surfaces ca...