Biomimetic Cascade Strategies Towards 2-Aminoindolines From Alkaloids

The 2-aminoindoline scaffold is abundant in natural alkaloids with antibacterial, antitumor and anti-inflammatory activities. Synthetic organic chemists have developed various elegant strategies towards this heterocyclic core. These strategies often entail a cascading sequence, where two or more bonds are formed simultaneously. Potentially, these approaches drastically decrease the number of reaction steps required typically minimizing waste generation and energy consumption. These features are a requisite for the present development of new and accessible more greener pharmaceuticals. This review will uncover the synthetic cascade toolbox towards the 2-aminoindolines core focussing on synthetic applicability and discussing the different reaction mechanisms involve