Add to ORKGThe hedgehog pathway, consisting partly of patched-1 (PTCH1) and smoothened (SMO), is essential in the development of basal cell carcinomas (BCCs). In 2012 vismodegib, a hedgehog pathway inhibitor, registered for the treatment of advanced BCCs (aBCCs). In daily practice, vismodegib is also used for patients with basal cell nevus syndrome (BCNS). This syndrome is caused by a germline or postzygotic mutation in PTCH1, and is therefore characterized by the early development of multiple BCCs. Although response rates to vismodegib is high, patients reported a many side effects. Due to these side effects, vismodegib is not ideal for the lifelong treatment of BCCs in BCNS-patients. Furthermore, a lot of aBCCs in non-BCNS patients develop resistanc...
The inappropriate activation of Hedgehog (Hh) pathway is involved in the pathogenesis of skin basal ...
Activating mutations in the Hh pathway underlies the development of sporadic and familial skin BCC. ...
Basal cell carcinoma (BCC) is a distinctive manifestation in nevoid basal cell carcinoma syndrome (N...
The hedgehog pathway, consisting partly of patched-1 (PTCH1) and smoothened (SMO), is essential in t...
Basal-cell carcinoma is the most common form of skin cancer and usually easiest to treat. The hedgeh...
Abstract: Basal cell carcinoma (BCC) is the most common human malignancy. Recent advances in our und...
Although basal cell carcinoma (BCC) is the most common cancer worldwide, its metastatic disseminatio...
Basal cell carcinoma (BCC), the most common type of skin cancer, is occasionally aggressive with dee...
The advent of more sophisticated studies published has clarified the understating of the root cause ...
Abnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell ...
Abnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell ...
Basal cell carcinomas (BCCs) are very common epithelial cancers that depend on the Hedgehog pathway ...
Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40%...
International audienceAbnormal activation of hedgehog pathway signaling is a key driver in the patho...
Muzafar A Macha,1 Surinder K Batra,1,2 Apar Kishor Ganti3,41Department of Biochemistry and Molecular...
The inappropriate activation of Hedgehog (Hh) pathway is involved in the pathogenesis of skin basal ...
Activating mutations in the Hh pathway underlies the development of sporadic and familial skin BCC. ...
Basal cell carcinoma (BCC) is a distinctive manifestation in nevoid basal cell carcinoma syndrome (N...
The hedgehog pathway, consisting partly of patched-1 (PTCH1) and smoothened (SMO), is essential in t...
Basal-cell carcinoma is the most common form of skin cancer and usually easiest to treat. The hedgeh...
Abstract: Basal cell carcinoma (BCC) is the most common human malignancy. Recent advances in our und...
Although basal cell carcinoma (BCC) is the most common cancer worldwide, its metastatic disseminatio...
Basal cell carcinoma (BCC), the most common type of skin cancer, is occasionally aggressive with dee...
The advent of more sophisticated studies published has clarified the understating of the root cause ...
Abnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell ...
Abnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell ...
Basal cell carcinomas (BCCs) are very common epithelial cancers that depend on the Hedgehog pathway ...
Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40%...
International audienceAbnormal activation of hedgehog pathway signaling is a key driver in the patho...
Muzafar A Macha,1 Surinder K Batra,1,2 Apar Kishor Ganti3,41Department of Biochemistry and Molecular...
The inappropriate activation of Hedgehog (Hh) pathway is involved in the pathogenesis of skin basal ...
Activating mutations in the Hh pathway underlies the development of sporadic and familial skin BCC. ...
Basal cell carcinoma (BCC) is a distinctive manifestation in nevoid basal cell carcinoma syndrome (N...