Impact of the number of LMCs on the overall flow rate changes in different vessel types.

(A) Top: Map of the network C57BL/6I and visualisation of the three scenarios with many, few and no LMCs. For the 50% scenario, only the pink-coloured LMCs are kept. The grey shaded area highlights the region within 250 μm to LMCs. Bottom: Colour map for the results displayed in panels B-F. (B) Relative changes of mean flow rates in MCA and ACA SAs of individual networks (markers) and averaged over all datasets (bars). The SAs are classified into vessels on a shortest path to LMCs (top) and others (bottom) (see Fig 3C). (C-D) Relative changes of integral flow rates computed over all MCA and ACA sided DAs (C) and for DAs located within 250 μm of LMCs only (D). The integral flow rate is defined as the sum of flow rates over all vessels of the respective vessel category (S7 Table). (E-F) Relative changes of integral flow rates in Cs in the entire network (E) and within 250 μm of LMCs (F).