S2 Fig -

Sensitivity study–Collagen fibril orientation weight (α). Top: Low-density collagen results for simulations where the fibril weight (α) was varied from 0.0–1.0. Here, 0 indicates vessel grow along the persistence direction while 1 indicates that vessels grow entirely along the sampled fibril direction. Plotted is the ratio of the major and minor semiprincipal axes for ODFs of microvascular orientation. Discrete fibril approaches and continuous EFD approaches to representing matrix fibril distributions were compared to prior experimental measures (target) for simulations of growth in low, medium, or high anisotropy collagen. Bottom: Similar results were generated from simulations with high-density matrix collagen. (TIF)