Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis
- Gibbons, James T.D.
- Course, Christopher
- Evans, Emily E.
- Kotecha, Sailesh
- Kotecha, Sarah
- Simpson, Shannon J.
- Kotecha, Sailesh
DOIAbstract
Few studies exist investigating lung function trajectories of those born preterm, however growing evidence suggests some individuals experience increasing airway obstruction throughout life. Here we use the studies identified in a recent systematic review to provide the first meta-analysis investigating the impact of preterm birth on airway obstruction measured by the FEV1/FVC ratio. Cohorts were included for analysis if they reported FEV1/FVC in survivors of preterm birth (<37 weeks’ gestation) and control populations born at term. Meta-analysis was performed using a random effect model, expressed as standardised mean difference (SMD). Meta-regression was conducted using age and birth year as moderators. 55 cohorts were eligible, 35 of w...
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