In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection into mammalian oocytes triggers calcium (Ca2+) oscillations indistinguishable from those observed at fertilization. The imperative role of PLCZ1 in oocyte activation is revealed by the vast number of human mutations throughout the PLCZ1 gene that have been identified and directly linked with certain forms of male infertility due to oocyte activation deficiency. PLCZ1 is the smallest PLC in size, comprising four N-terminal EF-hand domains, followed by X and Y catalytic domains, which are separated by the XY-linker, and...
Mammalian oocyte activation is thought to be caused by a sperm borne PLC subtype, called phospholipa...
Sperm-specific phospholipase C zeta (PLC?) is widely considered to be the physiological stimulus tha...
International audienceIn mammals, sperm-oocyte fusion initiates Ca(2+) oscillations leading to a ser...
In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it ...
Background: In mammals, oocyte activation at fertilization is thought to be induced by the sperm-s...
In mammals, oocyte activation at fertilization is thought to be induced by the sperm-specific phosph...
BACKGROUND: In mammals, oocyte activation at fertilization is thought to be induced by the sperm-spe...
General consensus agrees that the oscillations in intracellular calcium (Ca2+) leading to oocyte act...
General consensus agrees that the oscillations in intracellular calcium (Ca2+) leading to oocyte act...
It is widely believed that the sperm-specific protein phospholipase C zeta (PLCζ) is released into ...
Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of charac...
Sperm-specific phospholipase C zeta (PLC zeta) is widely considered to be the physiological stimulus...
Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of charac...
AbstractSignificant evidence now supports the assertion that cytosolic calcium oscillations during f...
A major unresolved issue in developmental biology is the precise mechanism whereby the sperm activat...
Mammalian oocyte activation is thought to be caused by a sperm borne PLC subtype, called phospholipa...
Sperm-specific phospholipase C zeta (PLC?) is widely considered to be the physiological stimulus tha...
International audienceIn mammals, sperm-oocyte fusion initiates Ca(2+) oscillations leading to a ser...
In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it ...
Background: In mammals, oocyte activation at fertilization is thought to be induced by the sperm-s...
In mammals, oocyte activation at fertilization is thought to be induced by the sperm-specific phosph...
BACKGROUND: In mammals, oocyte activation at fertilization is thought to be induced by the sperm-spe...
General consensus agrees that the oscillations in intracellular calcium (Ca2+) leading to oocyte act...
General consensus agrees that the oscillations in intracellular calcium (Ca2+) leading to oocyte act...
It is widely believed that the sperm-specific protein phospholipase C zeta (PLCζ) is released into ...
Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of charac...
Sperm-specific phospholipase C zeta (PLC zeta) is widely considered to be the physiological stimulus...
Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of charac...
AbstractSignificant evidence now supports the assertion that cytosolic calcium oscillations during f...
A major unresolved issue in developmental biology is the precise mechanism whereby the sperm activat...
Mammalian oocyte activation is thought to be caused by a sperm borne PLC subtype, called phospholipa...
Sperm-specific phospholipase C zeta (PLC?) is widely considered to be the physiological stimulus tha...
International audienceIn mammals, sperm-oocyte fusion initiates Ca(2+) oscillations leading to a ser...