α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in the vertebrate nervous system. α-synuclein functions in neurotransmitter release by binding to and clustering synaptic vesicles and chaperoning SNARE-complex assembly. Pathologically, aggregates originating from soluble pools of α-synuclein are deposited into Lewy bodies in Parkinson’s disease and related synucleinopathies. The functions of β-synuclein and γ-synuclein in presynaptic terminals remain poorly studied. Using in vitro liposome binding studies, circular dichroism spectroscopy, immunoprecipitation, and fluorescence resonance energy transfer (FRET) experiments on isolated synaptic vesicles in combination with subcellular fractionation of brains from synu...
AbstractAggregation of α-synuclein is involved in the pathogenesis of Parkinson's disease (PD). Stud...
α-Synuclein (α-syn) is a presynaptic protein present at most nerve terminals, but its function remai...
In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a co...
α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in the vertebrate nervou...
Recently, Parkinson’s disease-associated α-synuclein (αS) has emerged as an important regulator for ...
SummaryThe protein α-synuclein accumulates in the brain of patients with sporadic Parkinson's diseas...
Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesi...
α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of Parkinson’s di...
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological...
Synucleins, a family of three proteins highly expressed in neurons, are predominantly known for the ...
Aggregation of presynaptic protein α-synuclein is implicated in the development of Parkinson’s disea...
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attributi...
SummaryThe normal functions and pathologic facets of the small presynaptic protein α-synuclein (α-sy...
AbstractAlpha-synuclein (αSyn) interferes with multiple steps of synaptic activity at pre-and post-s...
In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a co...
AbstractAggregation of α-synuclein is involved in the pathogenesis of Parkinson's disease (PD). Stud...
α-Synuclein (α-syn) is a presynaptic protein present at most nerve terminals, but its function remai...
In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a co...
α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in the vertebrate nervou...
Recently, Parkinson’s disease-associated α-synuclein (αS) has emerged as an important regulator for ...
SummaryThe protein α-synuclein accumulates in the brain of patients with sporadic Parkinson's diseas...
Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesi...
α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of Parkinson’s di...
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological...
Synucleins, a family of three proteins highly expressed in neurons, are predominantly known for the ...
Aggregation of presynaptic protein α-synuclein is implicated in the development of Parkinson’s disea...
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attributi...
SummaryThe normal functions and pathologic facets of the small presynaptic protein α-synuclein (α-sy...
AbstractAlpha-synuclein (αSyn) interferes with multiple steps of synaptic activity at pre-and post-s...
In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a co...
AbstractAggregation of α-synuclein is involved in the pathogenesis of Parkinson's disease (PD). Stud...
α-Synuclein (α-syn) is a presynaptic protein present at most nerve terminals, but its function remai...
In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a co...