Feedback

One-pot conversion of allylic alcohols to α-methyl ketones via iron-catalyzed isomerization-methylation

  • Latham, Daniel E.
  • Polidano, Kurt
  • Williams, Jonathan M. J.
  • Morrill, Louis C.
Open PDF
Open link
Publication date
September 2019
Icon DOI
10.1021/acs.orglett.9b02900
Publisher
American Chemical Society

Abstract

A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization–methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization–methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield)

Extracted data

We use cookies to provide a better user experience.
Data Protection