The aim of the first part of this thesis was to determine the role played by IGF-IR in mediating the growth of EGFR-positive tamoxifen-resistant variants of MCF-7 Tam-R and T47D T47D-R breast cancer cell lines. The results identify a general tamoxifen-resistant mechanism whereby the autocrine release and action of IGF-II, mediated through the IGF-IR, plays a significant and crucial supporting role in regulating basal EGFR/MAPK signalling and cell proliferation and this occurs via a c-SRC-dependent mechanism in both Tam-R and T47D-R cells. The latter aim of this thesis was to determine further mechanisms of cross-talk between EGFR and IGF-IR in a range of EGFR-positive cancer cell lines. These studies identified a novel physical interaction ...
Aim: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
AIM: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
Aim: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
There is considerable evidence that the epidermal growth factor receptor (EGFR) and IGF-I receptor (...
Classically the insulin receptor substrate-1 (IRS-1) is an essential component of insulin-like growt...
De novo and acquired resistance to the anti-tumour drug gefitinib (ZD1839; Iressa), a specific epide...
De novo and acquired resistance to the anti-tumour drug gefitinib (ZD1839; Iressa), a specific epide...
Insulin-like growth factor-I receptor (IGF-IR) is integral to cancer cell proliferation, survival, m...
The development of tamoxifen resistance (TamR) in oestrogen receptor positive (ER+) breast cancer is...
The relationship between oestrogen (E2) and insulin-like growth factor-one (IGF-1) was examined in b...
Aberrant signalling through the epidermal growth factor receptor (EGFR) is associated with increased...
4Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IG...
The tyrosine kinase signaling pathway is an important pathway for cell signal transduction, and is i...
Insulin-like growth factor receptor (IGF-IR) signalling classically involves phosphorylation of insu...
Insulin-like growth factors (IGFs) and insulin are main regulators of cell growth in human and in an...
Aim: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
AIM: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
Aim: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
There is considerable evidence that the epidermal growth factor receptor (EGFR) and IGF-I receptor (...
Classically the insulin receptor substrate-1 (IRS-1) is an essential component of insulin-like growt...
De novo and acquired resistance to the anti-tumour drug gefitinib (ZD1839; Iressa), a specific epide...
De novo and acquired resistance to the anti-tumour drug gefitinib (ZD1839; Iressa), a specific epide...
Insulin-like growth factor-I receptor (IGF-IR) is integral to cancer cell proliferation, survival, m...
The development of tamoxifen resistance (TamR) in oestrogen receptor positive (ER+) breast cancer is...
The relationship between oestrogen (E2) and insulin-like growth factor-one (IGF-1) was examined in b...
Aberrant signalling through the epidermal growth factor receptor (EGFR) is associated with increased...
4Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IG...
The tyrosine kinase signaling pathway is an important pathway for cell signal transduction, and is i...
Insulin-like growth factor receptor (IGF-IR) signalling classically involves phosphorylation of insu...
Insulin-like growth factors (IGFs) and insulin are main regulators of cell growth in human and in an...
Aim: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
AIM: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...
Aim: Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell grow...