CD4+CD25+ regulatory T cells (Treg) are known to inhibit T cell responses however their site of action and whether they suppress other immune responses has not been well characterised. Using a model of tumour rejection involving a melanoma cell line expressing Fas ligand (B16FasL) the effect of Treg on these responses has been studied. NK cells and macrophages were found to play a critical role in rejection of B16FasL. Depletion of Treg enhanced tumour rejection, whilst adoptive transfer of Treg inhibited tumour rejection, indicating that Treg suppress innate immune responses. Experiments performed to identify the Treg target indicated that Treg inhibit the cytolytic activity of NK cells. Furthermore, depletion of Treg enhanced the inflamma...
MD (res)Once an immune response is initiated, a combination of several mechanisms coordinates and di...
Suppression by T regulatory cells (Tregs) is a major mechanism by which the immune system controls ...
Regulatory T cells (Treg) play a key role in the negative regulation of the immune system, which can...
CD4+CD25+ regulatory T cells (Treg) are known to inhibit T cell responses however their site of acti...
The T cell receptor (TCR) repertoires of Tregs and Tconv cells within the MCA induced tumours were a...
The T cell receptor (TCR) repertoires of Tregs and Tconv cells within the MCA induced tumours were a...
A population of T cells identified as CD4+CD25+FOXP3+ (Tregs) are present in rodents and humans. The...
CD4+ CD25+ regulatory T cells (Treg) have been shown to suppress tumour-specific T cell responses...
Regulatory T cells (Tregs) are a distinct lymphocyte lineage, functionally defined as T cells that i...
<p>Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (TReg) are a cell lineage that develops in...
Thesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Microbiology and...
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in m...
Although the immune system is rapidly becoming a key target for cancer treatment we still lack a com...
CD4+CD25+ regulatory T cells (Treg) are known to influence T cell responses to tumours. Here we have...
CD4+CD25+ regulatory T cells (Treg) are known to influence T cell responses to tumours. Here we have...
MD (res)Once an immune response is initiated, a combination of several mechanisms coordinates and di...
Suppression by T regulatory cells (Tregs) is a major mechanism by which the immune system controls ...
Regulatory T cells (Treg) play a key role in the negative regulation of the immune system, which can...
CD4+CD25+ regulatory T cells (Treg) are known to inhibit T cell responses however their site of acti...
The T cell receptor (TCR) repertoires of Tregs and Tconv cells within the MCA induced tumours were a...
The T cell receptor (TCR) repertoires of Tregs and Tconv cells within the MCA induced tumours were a...
A population of T cells identified as CD4+CD25+FOXP3+ (Tregs) are present in rodents and humans. The...
CD4+ CD25+ regulatory T cells (Treg) have been shown to suppress tumour-specific T cell responses...
Regulatory T cells (Tregs) are a distinct lymphocyte lineage, functionally defined as T cells that i...
<p>Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (TReg) are a cell lineage that develops in...
Thesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Microbiology and...
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in m...
Although the immune system is rapidly becoming a key target for cancer treatment we still lack a com...
CD4+CD25+ regulatory T cells (Treg) are known to influence T cell responses to tumours. Here we have...
CD4+CD25+ regulatory T cells (Treg) are known to influence T cell responses to tumours. Here we have...
MD (res)Once an immune response is initiated, a combination of several mechanisms coordinates and di...
Suppression by T regulatory cells (Tregs) is a major mechanism by which the immune system controls ...
Regulatory T cells (Treg) play a key role in the negative regulation of the immune system, which can...