Topics
nitric oxideChemical substance
virusAnimal
homozygousDisease
T lymphocytesAnatomical structure
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myocarditisDisease
mouseMammal
CoxsackievirusSpecies
The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of inducible nitric oxide synthase (NOS2; EC 1.14.13.39) in macrophages, the precise role of NOS2 in the host response to Coxsackievirus myocarditis has been unclear. We show, by using mice homozygous for a disrupted NOS2 allele, that Coxsackievirus replicates to higher titers in NOS22/2 mice, that the host lacking NOS2 clears virus more slowly than the wild-type host, and that myocarditis is much more severe in infected NOS22/2 mice. These data show that NOS2 is crucial for the host response to Coxsackievirus in the mouse
Coxsackievirus group B (CVB) is a common virus that usually causes only mild symptoms in humans. How...
grantor: University of TorontoViral myocarditis is an important cause of heart failure and...
NOS2 gene-deficient (NOS2-/-) mice are less susceptible than wild-type (NOS2+/+) mice to infection w...
The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, ...
Ongoing coxsackievirus B3 (CVB3) myocarditis is characterized by persistence of viral RNA and chroni...
AbstractObjectives. This study sought to investigate the effects of nitric oxide inhibition in a mur...
AbstractCoxsackieviral infections have been linked etiologically to multiple diseases. The serotype ...
Group B coxsackieviruses (CVB) are etiological agents of a febrile exanthematous disease that may b...
To investigate whether successful host defense against Pneumocystis carinii is dependent on inductio...
Both, innate and cell-mediated immunity contribute to prevention of chronic myocarditis and consecut...
Myocarditis-induced dilated cardiomyopathy is a major cause of heart disease and sudden death in you...
Innate resistance to flaviviruses in mice is active in the brain where it restricts virus replicatio...
Cytomegalovirus (CMV) is a typical pathogen of an opportunistic infection. In this review article, v...
Coxsackievirus A2 (CVA2) has emerged as an active pathogen that has been implicated in hand, foot, a...
Mice deficient in the inducible nitric-oxide synthase (iNOS), constructed by gene-targeting, were si...
Coxsackievirus group B (CVB) is a common virus that usually causes only mild symptoms in humans. How...
grantor: University of TorontoViral myocarditis is an important cause of heart failure and...
NOS2 gene-deficient (NOS2-/-) mice are less susceptible than wild-type (NOS2+/+) mice to infection w...
The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, ...
Ongoing coxsackievirus B3 (CVB3) myocarditis is characterized by persistence of viral RNA and chroni...
AbstractObjectives. This study sought to investigate the effects of nitric oxide inhibition in a mur...
AbstractCoxsackieviral infections have been linked etiologically to multiple diseases. The serotype ...
Group B coxsackieviruses (CVB) are etiological agents of a febrile exanthematous disease that may b...
To investigate whether successful host defense against Pneumocystis carinii is dependent on inductio...
Both, innate and cell-mediated immunity contribute to prevention of chronic myocarditis and consecut...
Myocarditis-induced dilated cardiomyopathy is a major cause of heart disease and sudden death in you...
Innate resistance to flaviviruses in mice is active in the brain where it restricts virus replicatio...
Cytomegalovirus (CMV) is a typical pathogen of an opportunistic infection. In this review article, v...
Coxsackievirus A2 (CVA2) has emerged as an active pathogen that has been implicated in hand, foot, a...
Mice deficient in the inducible nitric-oxide synthase (iNOS), constructed by gene-targeting, were si...
Coxsackievirus group B (CVB) is a common virus that usually causes only mild symptoms in humans. How...
grantor: University of TorontoViral myocarditis is an important cause of heart failure and...
NOS2 gene-deficient (NOS2-/-) mice are less susceptible than wild-type (NOS2+/+) mice to infection w...
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