A two-stage meta-analysis identifies several new loci for Parkinson's Disease
- Morris, Huw Rees
- Pearson, Justin P.
- Williams, Nigel Melville
- Wickremaratchi, Mirdhu
- International Parkinson's Disease Genomics Consortium (IPDGC)
- Wellcome Trust Case Control Consortium (WTCCC)
DOIAbstract
A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p<5×10−10, PARK16/1q32, STX1B/16p11, FGF20/8p22, STBD1/4q21, and GPNMB/7p15). Two of these five loci have been suggested by previous associ...
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