Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
- O'Donovan, Michael Conlon
- Norton, Nadine
- Williams, Hywel John
- Peirce, Timothy Rowan
- Escott-Price, Valentina
- Nikolov, Ivan
- Hamshere, Marian Lindsay
- Carroll, Liam Stuart
- Georgieva, Lyudmila
- Dwyer, Sarah Lynne
- Holmans, Peter Alan
- Marchini, J. L.
- Spencer, C. C. A.
- Howie, B.
- Leung, H.T.
- Giegling, I.
- Hartmann, A. M.
- Möller, H.J.
- Morris, D. W.
- Shi, Y.
- Feng, G.
- Hoffmann, P.
- Propping, P.
- Vasilescu, C.
- Maier, W.
- Rietschel, M.
- Zammit, Stanley
- Schumacher, J.
- Quinn, E. M.
- Schulze, T. G.
- Iwata, N.
- Ikeda, M.
- Darvasi, A.
- Shifman, S.
- He, L.
- Duan, J.
- Sanders, A. R.
- Levinson, D. F.
- Adolfsson, R.
- Ösby, U.
- Terenius, L
- Jönsson, E. G.
- Cichon, S.
- Nöthen, M. M.
- Gill, M.
- Corvin, A. P.
- Rujescu, D.
- Gejman, P. V.
- Kirov, George
- Craddock, Nicholas John
- Williams, Nigel Melville
- Owen, Michael John
DOIAbstract
We and others have previously reported linkage to schizophrenia on chromosome 10q25–q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25–q26 that had been typed in a genome-wide association study (GWAS) of schizophrenia (479 UK cases/2937 controls). SNPs with P<0.01 (n=40) were genotyped in an additional 163 UK cases and those markers that remained nominally significant at P<0.01 (n=22) were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of 1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally significant after meta-analyses across the replication samples a...
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