Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
- Green, Elaine Karen
- Grozeva, Detelina
- Escott-Price, Valentina
- Hamshere, Marian Lindsay
- Jones, Ian Richard
- Jones, Lisa
- Forty, Elizabeth
- Caesar, Sian
- Gordon-Smith, Katherine
- Fraser, Christine
- Russell, Elen
- St Clair, David
- Young, Allan H.
- Ferrier, Nicol
- Farmer, Anne
- McGuffin, Peter
- Holmans, Peter Alan
- Owen, Michael John
- O'Donovan, Michael Conlon
- Craddock, Nicholas John
DOIAbstract
We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052)
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