Add to ORKGThe synthesis of a series of α-l-2'-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, C and U is described in seven steps from 1,2-O-isopropyledene-α-l-threose, involving a Vorbrüggen coupling and a Barton-McCombie deoxygenation protocol as the key steps. All analogues, including a phosphoramidate nucleoside phosphate prodrug of the T analogue, were evaluated against a broad panel of different viruses but found inactive, while also lacking notable cellular toxicity. The thymidine analogue showed inhibition to mitochondrial thymidine kinase-2 (TK-2), herpes simplex virus type 1 (HSV-1) TK, varicella-zoster virus (VZV) TK and Mycobacterium tuberculosis thymidylate kinase
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Nucleoside analogues are an important class of antimetabolites, used both as anticancer and antivira...
The synthesis of pyrimidine unsaturated keto and exomethylene arabinopyranonucleoside analogs as pot...
The synthesis of a series of α-l-2'-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
The synthesis of a series of α-l-2'-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
The synthesis of a series of α-l-2′-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
The synthesis of a series of α-l-2'-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
L-α-2′-Deoxythreosyl nucleoside phosphonates and their phosphonodiamidate prodrugs with a hypoxanthi...
The synthesis of both 2'-hydroxy-3'-deoxy and 2'-deoxy-3'-hydroxy cyclopentyl nucleoside phosphonate...
To assess the structure-activity relationship for antiviral activity, a series of 3'-deoxy-3'-N-func...
A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragm...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
BACKGROUND: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Nucleoside analogues are an important class of antimetabolites, used both as anticancer and antivira...
The synthesis of pyrimidine unsaturated keto and exomethylene arabinopyranonucleoside analogs as pot...
The synthesis of a series of α-l-2'-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
The synthesis of a series of α-l-2'-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
The synthesis of a series of α-l-2′-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
The synthesis of a series of α-l-2'-deoxythreofuranosyl nucleosides featuring the nucleobases A, T, ...
L-α-2′-Deoxythreosyl nucleoside phosphonates and their phosphonodiamidate prodrugs with a hypoxanthi...
The synthesis of both 2'-hydroxy-3'-deoxy and 2'-deoxy-3'-hydroxy cyclopentyl nucleoside phosphonate...
To assess the structure-activity relationship for antiviral activity, a series of 3'-deoxy-3'-N-func...
A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragm...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
BACKGROUND: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Background: Nucleoside analogues always require phosphorylation to be active. This appears to be a p...
Nucleoside analogues are an important class of antimetabolites, used both as anticancer and antivira...
The synthesis of pyrimidine unsaturated keto and exomethylene arabinopyranonucleoside analogs as pot...