Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate
- Dunn, Warwick B.
- Broadhurst, David
- Deepak, Sasalu
- Buch, Mamta
- McDowell, Garry
- Spasic, Irena
- Ellis, David I.
- Brooks, Nicholas
- Kell, Douglas B.
- Neyses, Ludwig
DOIAbstract
There is intense interest in the identification of novel biomarkers which improve the diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF <40% plus signs and symptoms of failure) and 57 controls were analyzed by gas chromatography – time of flight – mass spectrometry and the raw data reduced to 272 statistically robust metabolite peaks. 38 peaks showed a significant difference between case and control (p<5·10)5). Two such metabolites were pseudouridine, a modified nucleotide present in t- and rRNA and a marker of cell turnover, as well as the tricarboxylic acid cycle intermediate 2-oxoglutarate. Furthermore, 3 further new compounds were also excellent discriminators between patients and controls: ...
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