Prior infection can generate protective immunity against subsequent infection, although the efficacy of such immunity can vary considerably. Live-attenuated vaccines (LAVs) are one of the most effective methods for mimicking this natural process, and analysis of their efficacy has proven instrumental in the identification of protective immune mechanisms. Here, we address the question of what makes a LAV efficacious by characterising immune responses to a LAV, termed TAS2010, which is highly protective (80-90%) against lethal murine salmonellosis, in comparison with a moderately protective (40-50%) LAV, BRD509. Mice vaccinated with TAS2010 developed immunity systemically and were protected against gut-associated virulent infection in a CD4+ ...
Salmonella enterica serovars are intracellular bacteria capable of causing typhoid fever and gastroe...
<p>C57BL/6 mice were infected orally with 1×10<sup>7</sup> virulent <i>Salmonella</i> Typhimurium. G...
Understanding immune responses elicited by vaccines, together with immune responses required for pro...
While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of ...
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen wher...
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a del...
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a del...
The SL3261 Salmonella typhimurium aro A live vaccine strain confers solid protection against oral ch...
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a del...
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen wher...
Wild-type C57BL/6 mice were either naïve or i.v. injected with 200cfu TAS2010 or BRD509, and the spl...
The mechanisms of immunity to salmonellae conferred by immunization with live vaccines were studied ...
Here I examine the properties of a live Salmonella-based vaccine and a mucosal adjuvant based on a b...
Salmonella typhi is the causative organism for typhoid fever, a serious systemic disease in humans. ...
<div><p>Live attenuated vaccines are of great value for preventing infectious diseases. They represe...
Salmonella enterica serovars are intracellular bacteria capable of causing typhoid fever and gastroe...
<p>C57BL/6 mice were infected orally with 1×10<sup>7</sup> virulent <i>Salmonella</i> Typhimurium. G...
Understanding immune responses elicited by vaccines, together with immune responses required for pro...
While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of ...
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen wher...
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a del...
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a del...
The SL3261 Salmonella typhimurium aro A live vaccine strain confers solid protection against oral ch...
Live attenuated vaccines are of great value for preventing infectious diseases. They represent a del...
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen wher...
Wild-type C57BL/6 mice were either naïve or i.v. injected with 200cfu TAS2010 or BRD509, and the spl...
The mechanisms of immunity to salmonellae conferred by immunization with live vaccines were studied ...
Here I examine the properties of a live Salmonella-based vaccine and a mucosal adjuvant based on a b...
Salmonella typhi is the causative organism for typhoid fever, a serious systemic disease in humans. ...
<div><p>Live attenuated vaccines are of great value for preventing infectious diseases. They represe...
Salmonella enterica serovars are intracellular bacteria capable of causing typhoid fever and gastroe...
<p>C57BL/6 mice were infected orally with 1×10<sup>7</sup> virulent <i>Salmonella</i> Typhimurium. G...
Understanding immune responses elicited by vaccines, together with immune responses required for pro...