Brain hemodynamic intermediate phenotype links Vitamin B12 to cognitive profile of healthy and mild cognitive impaired subjects
- Cecchetti L.
- Lettieri G.
- Handjaras G.
- Leo A.
- Ricciardi E.
- Pietrini P.
- Pellegrini S.
- Andreassi M. G.
- Angelucci A.
- Baldacci F.
- Baroncelli L.
- Begenisic T.
- Bellinvia P. F.
- Biagi L.
- Bonaccorsi J.
- Bonanni E.
- Borghini A.
- Braschi C.
- Broccardi M.
- Caleo M.
- Carlesi C.
- Carnicelli L.
- Cartoni G.
- Cenni M. C.
- Ceravolo R.
- Chico L.
- Cioni G.
- Costa M.
- D'Ascanio P.
- De Nes M.
- Di Coscio E.
- Di Galante M.
- di Lascio N.
- Faita F.
- Falorni I.
- Faraguna U.
- Fenu A.
- Fortunato L.
- Franco R.
- Gargiulo R.
- Giorgi F. S.
- Iannarella R.
- Iofrida C.
- Kusmic C.
- Limongi F.
- Maestri M.
- Maffei M.
- Maggi S.
- Mainardi M.
- Mammana L.
- Marabotti A.
- Mariotti V.
- Melissari E.
- Mercuri A.
- Molinaro S.
- Narducci R.
- Navarra T.
- Noale M.
- Pagni C.
- Palumbo S.
- Pasquariello R.
- Pizzorusso T.
- Poli A.
- Retico A.
- Rota G.
- Sale A.
- Scabia G.
- Scali M.
- Scelfo D.
- Siciliano G.
- Tonacci A.
- Tosetti M.
- Turchi S.
- Volpi L.
DOIAbstract
Vitamin B12, folate, and homocysteine are implicated in pivotal neurodegenerative mechanisms and partake in elders' mental decline. Findings on the association between vitamin-related biochemistry and cognitive abilities suggest that the structural and functional properties of the brain may represent an intermediate biomarker linking vitamin concentrations to cognition. Despite this, no previous study directly investigated whether vitamin B12, folate, and homocysteine levels are sufficient to explain individual neuropsychological profiles or, alternatively, whether the activity of brain regions modulated by these compounds better predicts cognition in elders. Here, we measured the relationship between vitamin blood concentrations, scores at...
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