The impact of variant and vaccination on SARS-CoV-2 symptomatology; three prospective household cohorts
- Westerhof, Ilse
- de Hoog, Marieke
- Ieven, Margareta
- Lammens, Christine
- van Beek, Janko
- Rozhnova, Ganna
- Eggink, Dirk
- Euser, Sjoerd
- Wildenbeest, Joanne
- Duijts, Liesbeth
- van Houten, Marlies
- Goossens, Herman
- Giaquinto, Carlo
- Bruijning-Verhagen, Patricia
DOIAbstract
Objectives: We compared age-stratified SARS-CoV-2 symptomatology of wild-type/Alpha vs Omicron BA.1/BA.2 variant infected individuals and the impact of COVID-19 booster vaccination on Omicron symptom burden. Methods: Data from three European prospective household cohorts were used (April 2020 to April 2021 and January to March 2022). Standardized outbreak protocols included (repeated) polymerase chain reaction testing, paired serology, and daily symptom scoring for all household members. Comparative analyses were performed on 346 secondary household cases from both periods. Results: Children <12 years (all unvaccinated) experienced more symptoms and higher severity scores during Omicron compared with wild-type/Alpha period (P ≤0.01). In adu...
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