Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Blac...
Polygenic risk scores (PRS) for disease risk stratification show great promise for application in ge...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong herit...
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European wome...
Acknowledgements: National Cancer Institute, National Human Genome Research Institute (R01 CA244588 ...
BACKGROUND & AIMS: Genome-wide association studies (GWASs) have associated approximately 50 loci w...
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at ...
To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association ...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P -8) associate...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) a...
Purpose Non-European populations are under-represented in genetics studies, hindering clinical imple...
BACKGROUND: Risk variants identified so far for colorectal cancer explain only a small proportion of...
PURPOSE: Polygenic risk scores (PRSs) for breast cancer (BC) risk stratification have been developed...
BackgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) ...
Genome-wide association studies of colorectal cancer (CRC) have identified risk variants in 10 genom...
Background and aims: Summarised in polygenic risk scores (PRS), the effect of common, low penetrant ...
Polygenic risk scores (PRS) for disease risk stratification show great promise for application in ge...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong herit...
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European wome...
Acknowledgements: National Cancer Institute, National Human Genome Research Institute (R01 CA244588 ...
BACKGROUND & AIMS: Genome-wide association studies (GWASs) have associated approximately 50 loci w...
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at ...
To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association ...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P -8) associate...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) a...
Purpose Non-European populations are under-represented in genetics studies, hindering clinical imple...
BACKGROUND: Risk variants identified so far for colorectal cancer explain only a small proportion of...
PURPOSE: Polygenic risk scores (PRSs) for breast cancer (BC) risk stratification have been developed...
BackgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) ...
Genome-wide association studies of colorectal cancer (CRC) have identified risk variants in 10 genom...
Background and aims: Summarised in polygenic risk scores (PRS), the effect of common, low penetrant ...
Polygenic risk scores (PRS) for disease risk stratification show great promise for application in ge...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong herit...
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European wome...