Assessing a sustainable manufacturing route to lapatinib
- Stark, Roderick T.
- Pye, Dominic R.
- Chen, Wenyi
- Newton, Oliver J.
- Deadman, Benjamin J.
- Miller, Philip W.
- Panayides, Jenny-Lee
- Riley, Darren L.
- Hellgardt, Klaus
- Hii, King Kuok (Mimi)
DOIAbstract
A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.The ROAR facility by EPSRC.https://pubs.rsc.org/en/journals/journalissues/ream2023Chemistr
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