Following the enactment of a generic ban in China in 2021, the synthetic cannabinoid market has been evolving, now encompassing even wider structural diversity. Compounds carrying a brominated core such as ADB-5'Br-BUTINACA (ADMB-B-5Br-INACA) and tail-less analogs, such as ADB-5'Br-INACA (ADMB-5Br-INACA), MDMB-5'Br-INACA, and ADB-INACA (ADMB-INACA), have been detected since late 2021. This study investigated the cannabinoid receptor (CB) activation potential of synthesized (S)-enantiomers of these substances, as well as of two predicted analogs MDMB-5'Br-BUTINACA (MDMB-B-5Br-INACA) and ADB-5'F-BUTINACA (ADMB-B-5F-INACA), using CB1 and CB2 β-arrestin 2 recruitment assays and a CB1 intracellular calcium release assay. Surprisingly, the tail-l...
Indole and indazole synthetic cannabinoids (SCs) featuring l-valinate or l-tert-leucinate pendant gr...
Synthetic cannabinoid receptor agonists (SCRAs) are one of the largest and most structurally diverse...
The present work is the last of a three-part study investigating a panel of 30 systematically design...
Following the enactment of a generic ban in China in 2021, the synthetic cannabinoid market has been...
Following the class-wide ban of synthetic cannabinoid receptor agonists (SCRAs) in China, SCRAs carr...
In recent years, several nations have implemented various measures to control the surge of new synth...
The synthetic cannabinoid receptor agonist (SCRA) market is undergoing important changes since the e...
Synthetic cannabinoid receptor agonists (SCRAs) are an evolving class of new psychoactive substances...
Synthetic cannabinoid receptor agonists (SCRAs) are the second largest class of new psychoactive sub...
Synthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances (...
Indole and indazole synthetic cannabinoids (SCs) featuring l-valinate or l-tert-leucinate pendant gr...
Synthetic cannabinoid receptor agonists (SCRAs) are one of the largest and most structurally diverse...
The present work is the last of a three-part study investigating a panel of 30 systematically design...
Following the enactment of a generic ban in China in 2021, the synthetic cannabinoid market has been...
Following the class-wide ban of synthetic cannabinoid receptor agonists (SCRAs) in China, SCRAs carr...
In recent years, several nations have implemented various measures to control the surge of new synth...
The synthetic cannabinoid receptor agonist (SCRA) market is undergoing important changes since the e...
Synthetic cannabinoid receptor agonists (SCRAs) are an evolving class of new psychoactive substances...
Synthetic cannabinoid receptor agonists (SCRAs) are the second largest class of new psychoactive sub...
Synthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances (...
Indole and indazole synthetic cannabinoids (SCs) featuring l-valinate or l-tert-leucinate pendant gr...
Synthetic cannabinoid receptor agonists (SCRAs) are one of the largest and most structurally diverse...
The present work is the last of a three-part study investigating a panel of 30 systematically design...