Add to ORKGThe objective of the study is to find how the interactions erythromycin A (ERYA), a 14-membered ring macrolide, with a single base substitution from adenine to guanine on the large ribosomal subunit at 2041. This single base substitution has been reported of to be one of the resistance modes in the binding of macrolides. Molecular dynamics (MD) simulation is a great tool that was used in this study to explain at the molecular level why resistance happens when a single base substitution takes place at 2041, one of the residues in PTe
Abstract Aminoglycoside antibiotics are protein synthesis inhibitors applied to treat infections cau...
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein bi...
The current work reports on structural studies of ribonucleoprotein complexes, Escherichia coli and ...
<div><p>Resistance to macrolide antibiotics is conferred by mutation of A2058 to G or methylation by...
Resistance to macrolide antibiotics is conferred by mutation of A2058 to G or methylation by Erm met...
The ribosome is one of the most basic cellular machines and is ubiquitous in all living cells, respo...
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living ce...
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living ce...
Many processes in biology involve conformational changes or binding events which can be described by...
Molecular dynamics (MD) simulations are a powerful tool for describing the structure, dynamics, and ...
Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL pe...
AbstractAntimycin A is the most frequently used specific and powerful inhibitor of the mitochondrial...
abstract: Molecular dynamics (MD) simulations provide a particularly useful approach to understandin...
The ribosome is the molecular machine which reads and translates genetic information into proteins i...
Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL pe...
Abstract Aminoglycoside antibiotics are protein synthesis inhibitors applied to treat infections cau...
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein bi...
The current work reports on structural studies of ribonucleoprotein complexes, Escherichia coli and ...
<div><p>Resistance to macrolide antibiotics is conferred by mutation of A2058 to G or methylation by...
Resistance to macrolide antibiotics is conferred by mutation of A2058 to G or methylation by Erm met...
The ribosome is one of the most basic cellular machines and is ubiquitous in all living cells, respo...
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living ce...
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living ce...
Many processes in biology involve conformational changes or binding events which can be described by...
Molecular dynamics (MD) simulations are a powerful tool for describing the structure, dynamics, and ...
Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL pe...
AbstractAntimycin A is the most frequently used specific and powerful inhibitor of the mitochondrial...
abstract: Molecular dynamics (MD) simulations provide a particularly useful approach to understandin...
The ribosome is the molecular machine which reads and translates genetic information into proteins i...
Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL pe...
Abstract Aminoglycoside antibiotics are protein synthesis inhibitors applied to treat infections cau...
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein bi...
The current work reports on structural studies of ribonucleoprotein complexes, Escherichia coli and ...