Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression
- Liu, Xinyu
- Jiang, Liqin
- Ke, Mengyuan
- Sigal, Ian A.
- Chua, Jacqueline
- Hoang, Quan V.
- Chia, Audrey W. I.
- Najjar, Raymond P.
- Tan, Bingyao
- Cheong, Jocelyn
- Bellemo, Valentina
- Chong, Rachel S.
- Girard, Michaël J. A.
- Ang, Marcus
- Liu, Mengyang
- Garhöfer, Gerhard
- Barathi, Veluchamy A.
- Saw, Seang-Mei
- Villiger, Martin
- Schmetterer, Leopold
DOIAbstract
In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been observed ex vivo. Here we report the development of triple-input polarization-sensitive optical coherence tomography (OCT) for measuring posterior scleral birefringence. In guinea pigs and humans, the technique offers superior imaging sensitivities and accuracies than dual-input polarization-sensitive OCT. In 8-week-long studies with young guinea pigs, scleral birefringence was positively correlated with spherical equivalent refractive errors and predicted the onset of myopia. In a cross-sectional study involving adult individuals, scleral birefringence was associated with myopia status and negatively correlated with refractive errors. Triple-input ...
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