Arginine-based surfactants alter the rheological and in-plane structural properties of stratum corneum model membranes
- Hermet, Melisa
- Espinosa Silva, Yanis Ricardo
- Fait, María Elisa
- Zulueta Díaz, Yenisleidy de Las Mercedes
- Morcelle del Valle, Susana Raquel
- Bakas, Laura Susana
- Alvarez, Hugo Ariel
- Fanani, Maria Laura
DOIAbstract
Hypothesis: Amino acid-based surfactants have been proposed as skin permeation enhancers. In this work, we investigated the potentiality of two arginine-based amphiphiles as permeation enhancers by studying their interaction with stratum corneum (SC) model lipid membranes. Experiments: Nα-benzoyl arginine decyl- and dodecylamide were tested in comparison with the classical enhancer, oleic acid, and the non-enhancer, stearic acid. Two complementary approaches were used: lipid monolayers, taken as models of the unit film layer of SC, and atomistic molecular dynamics simulations. Findings: The arginine-based amphiphiles studied were able to be incorporated into the SCM membrane and alter its rheological and structural properties by disordering...
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