Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, for which there is no effective, low-cost, and low-toxicity treatment for the host. Naphthoquinones are ligands with redox properties involved in oxidative biological processes with a wide variety of activities, including antiparasitic. In this work, in silico methods of quantitative structure–activity relationship (QSAR), molecular docking, and calculation of ADME (absorption, distribution, metabolism, and excretion) properties were used to evaluate naphthoquinone derivatives with unknown antiprotozoal activity. QSAR models were developed for predicting antiparasitic activity against Trypanosoma cruzi, Leishmania amazonensis, and Leishmania ...
We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanoci...
A doença de Chagas causada pelo Trypanosoma cruzi afeta cerca de oito milhões de pessoas em países e...
Leishmaniasis is a group of vector-borne neglected diseases caused by intracellular protozoan parasi...
Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, ...
This work was supported by Ministerio de Ciencia e Innovacion (MICINN) (CTQ2011-22433, CTQ2012-30930...
AbstractHuman African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which are caused by t...
In this work we have collected a set of 30 trypanosomicidal naphthoquinones and developed pharmacoph...
Two series of pyrazol and propenone quinoxaline derivatives were tested for parasiticidal activity (...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pesso...
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a...
Leishmaniasis, caused by protozoa of the genus Leishmania, encompasses a group of neglected diseases...
The trypanosomatid parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania are the causative ...
none15siBackground and Methodology: Recently, we reported on a new class of naphthoquinone derivativ...
The present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba...
A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cau...
We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanoci...
A doença de Chagas causada pelo Trypanosoma cruzi afeta cerca de oito milhões de pessoas em países e...
Leishmaniasis is a group of vector-borne neglected diseases caused by intracellular protozoan parasi...
Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, ...
This work was supported by Ministerio de Ciencia e Innovacion (MICINN) (CTQ2011-22433, CTQ2012-30930...
AbstractHuman African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which are caused by t...
In this work we have collected a set of 30 trypanosomicidal naphthoquinones and developed pharmacoph...
Two series of pyrazol and propenone quinoxaline derivatives were tested for parasiticidal activity (...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pesso...
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a...
Leishmaniasis, caused by protozoa of the genus Leishmania, encompasses a group of neglected diseases...
The trypanosomatid parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania are the causative ...
none15siBackground and Methodology: Recently, we reported on a new class of naphthoquinone derivativ...
The present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba...
A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cau...
We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanoci...
A doença de Chagas causada pelo Trypanosoma cruzi afeta cerca de oito milhões de pessoas em países e...
Leishmaniasis is a group of vector-borne neglected diseases caused by intracellular protozoan parasi...