Humoral response to the BBIBP-CorV vaccine over time in healthcare workers with or without exposure to SARS-CoV-2
- Badano, Maria Noel
- Sabbione, Florencia
- Keitelman, Irene Angélica
- Pereson Moschen, Matias Javier
- Aloisi, Natalia
- Colado, Ana
- Ramos, Maria Victoria
- Ortiz Wilczyñski, Juan Manuel
- Pozner, Roberto Gabriel
- Castillo, Luis
- Wigdorovitz, Georgina
- Elizalde de Bracco, María Marta
- Fink, Susana
- Chuit, Roberto
- Baré, Patricia
DOIAbstract
SARS-CoV-2-specific humoral response was analyzed over time in a group of healthcare workers with or without exposure to SARS-CoV-2, who underwent vaccination with BBIBP-CorV (Sinopharm) vaccine in Argentina. Seroconversion rates in unexposed subjects after the first and second doses were 40 % and 100 %, respectively, showing a significant increase in antibody concentrations from dose 1 to dose 2 (p < 0.0001). The highest antibody concentrations were found in younger subjects and women, remaining significantly associated in a multivariable linear regression model (p = 0.005). A single dose of the BBIBP-CorV vaccine induced a strong antibody response in individuals with prior SARS-CoV-2infection, while a second dose did not increase this res...
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