Integrating Nextflow and AWS for Large-Scale Genomic Analysis: A Hypothetical Case Study

[EN]This article explores the innovative combination of Nextflow and Amazon Web Services (AWS) to address the challenges inherent in large-scale genomic analysis. Focusing on a hypothetical case called "The Pacific Genome Atlas", it illustrates how a research organization could approach the sequencing and analysis of 10,000 genomes. Although the "Pacific Genome Atlas" is a fictional example used for illustrative purposes only, it highlights the real challenges associated with large genomic projects, such as handling huge volumes of data and the need for intensive computational analysis. Through the integration of Nextflow, a workflow management tool, with the AWS cloud infrastructure, we demonstrate how these challenges can be overcome, offering scalable, flexible and cost-effective solutions for genomic research. The adoption of modern technologies, such as those described in this article, is essential to advance the field of genomics and accelerate scientific discoveries.The present study has been funded by the AIR Genomics project (file number CCTT3/20/SA/0003) through the 2020 call for R&D Projects Oriented towards Excellence and Competitive Improvement of CCTT by the Institute of Business Competitiveness of Castilla y León and FEDER fund