Figure S3.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

Table S6.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S6: List of genes clustered by Gene Ontology (GO) terms comprised in enriched biological proce...

Traits of a mussel transmissible cancer are reminiscent of a parasitic life style

Burioli, Erika A.V.
Hammel, M.
Bierne, Nicolas
Charrière, Guillaume
Thomas, F.
Houssin, Maryline
Destoumieux-Garzon, Delphine

December 2021

International audienceSome cancers have evolved the ability to spread from host to host by transmiss...

Prevalence and polymorphism of a mussel transmissible cancer in Europe.

Hammel, Maurine
Simon, Alexis
Arbiol, Christine
Villalba, Antonio
Burioli, Erika AV
Pépin, Jean-François
Lamy, Jean-Baptiste
Benabdelmouna, Abdellah
Bernard, Ismael
Houssin, Maryline
Charrière, Guillaume M
Destoumieux-Garzon, Delphine
Welch, John
Metzger, Michael J
Bierne, Nicolas

June 2021

Transmissible cancers are parasitic malignant cell lineages that have acquired the ability to infect...

Figure S2.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S2: Spearman's correlation (R2>0.87) between the expression levels (expressed as Log2(TMM+1))...

Table S4.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S4: List of the transcripts significantly differentially expressed with descriptions, Gene IDs...

Figure S4.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S4: Heatmap (log2 centred) with hierarchical clustering of the 4254 differentially expressed ...

Figure S6.jpeg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S6: Top-expressed transcripts of genes in whole flesh of MtrBTN2-affected additional samples ...

Table S5.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S5: List of the transcripts significantly differentially expressed with descriptions, Gene IDs...

Figure S1.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S1: Validation of the results obtained from RNAseq data by RT-qPCR quantification on 10 addit...

Figure S5.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S5: PCA based on the normalized read counts of healthy M. trossulus and M. edulis hemocytes (...

Figure S7.tif from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S7: RDA on normalized read counts to analyze the impact of explanatory variables (“cell type”...

Table S7.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S7: top 20 genes in connectivity ranking in Protein-protein interaction (PPI) networks of DEGs

Table S2.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S2: SRA accession numbers of individual raw read sequences deposited in the NCBI database

Table S8.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S8: SNVs present in all MtrBTN2 samples and absent in MtrBTN2-free samples. VAF, variant allel...

Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli
M. Hammel
E. Vignal
J. Vidal-Dupiol
G. Mitta
F. Thomas
N. Bierne
D. Destoumieux-Garzón
G. M. Charrière

October 2023

Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroa...

Table S6.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S6: List of genes clustered by Gene Ontology (GO) terms comprised in enriched biological proce...

Traits of a mussel transmissible cancer are reminiscent of a parasitic life style

Burioli, Erika A.V.
Hammel, M.
Bierne, Nicolas
Charrière, Guillaume
Thomas, F.
Houssin, Maryline
Destoumieux-Garzon, Delphine

December 2021

International audienceSome cancers have evolved the ability to spread from host to host by transmiss...

Prevalence and polymorphism of a mussel transmissible cancer in Europe.

Hammel, Maurine
Simon, Alexis
Arbiol, Christine
Villalba, Antonio
Burioli, Erika AV
Pépin, Jean-François
Lamy, Jean-Baptiste
Benabdelmouna, Abdellah
Bernard, Ismael
Houssin, Maryline
Charrière, Guillaume M
Destoumieux-Garzon, Delphine
Welch, John
Metzger, Michael J
Bierne, Nicolas

June 2021

Transmissible cancers are parasitic malignant cell lineages that have acquired the ability to infect...

Figure S2.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S2: Spearman's correlation (R2>0.87) between the expression levels (expressed as Log2(TMM+1))...

Table S4.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S4: List of the transcripts significantly differentially expressed with descriptions, Gene IDs...

Figure S4.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S4: Heatmap (log2 centred) with hierarchical clustering of the 4254 differentially expressed ...

Figure S6.jpeg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S6: Top-expressed transcripts of genes in whole flesh of MtrBTN2-affected additional samples ...

Table S5.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S5: List of the transcripts significantly differentially expressed with descriptions, Gene IDs...

Figure S1.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S1: Validation of the results obtained from RNAseq data by RT-qPCR quantification on 10 addit...

Figure S5.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S5: PCA based on the normalized read counts of healthy M. trossulus and M. edulis hemocytes (...

Figure S7.tif from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Figure S7: RDA on normalized read counts to analyze the impact of explanatory variables (“cell type”...

Table S7.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S7: top 20 genes in connectivity ranking in Protein-protein interaction (PPI) networks of DEGs

Table S2.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S2: SRA accession numbers of individual raw read sequences deposited in the NCBI database

Table S8.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S8: SNVs present in all MtrBTN2 samples and absent in MtrBTN2-free samples. VAF, variant allel...

Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli
M. Hammel
E. Vignal
J. Vidal-Dupiol
G. Mitta
F. Thomas
N. Bierne
D. Destoumieux-Garzón
G. M. Charrière

October 2023

Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroa...

Table S6.xlsx from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

E. A. V. Burioli (17121739)
M. Hammel (17121742)
E. Vignal (17121745)
J. Vidal-Dupiol (6309866)
G. Mitta (2643685)
F. Thomas (17121748)
N. Bierne (11964407)
D. Destoumieux-Garzón (17121751)
G. M. Charrière (17121754)

October 2023

Table S6: List of genes clustered by Gene Ontology (GO) terms comprised in enriched biological proce...

Traits of a mussel transmissible cancer are reminiscent of a parasitic life style

Burioli, Erika A.V.
Hammel, M.
Bierne, Nicolas
Charrière, Guillaume
Thomas, F.
Houssin, Maryline
Destoumieux-Garzon, Delphine

December 2021

International audienceSome cancers have evolved the ability to spread from host to host by transmiss...

Prevalence and polymorphism of a mussel transmissible cancer in Europe.

Hammel, Maurine
Simon, Alexis
Arbiol, Christine
Villalba, Antonio
Burioli, Erika AV
Pépin, Jean-François
Lamy, Jean-Baptiste
Benabdelmouna, Abdellah
Bernard, Ismael
Houssin, Maryline
Charrière, Guillaume M
Destoumieux-Garzon, Delphine
Welch, John
Metzger, Michael J
Bierne, Nicolas

June 2021

Transmissible cancers are parasitic malignant cell lineages that have acquired the ability to infect...

Figure S3.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

Abstract

Extracted data

Figure S3.jpg from Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

Abstract

Extracted data

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