Representation of data from Figs 6 and 7 as estimated dose response curves.

A panel of human prostate and cancer cells were seeded at optimized conditions and treated for 72-hours (as described in Figs 6 and 7) with A) the first-in-class BET and CBP/p300 dual inhibitor EP-31670 or B) the IGF-1R inhibitor linsitinib, respectively. For visualization, dose response curves were estimated using CellTiter-Glo endpoint viability at 72-hrs. Cellular drug response data were fit into a non-linear sigmoidal regression curve via and plotted together. Since the protocol screens only 5 drug concentrations, an algorithm to estimate these curves assigned values of Log(M) = -9 and Log(M) = -1 respectively to represent the two extremes of the curves (completely ineffective concentration and completely effective concentration). (TIF)