Comparison of five wild-type mouse femurs to the core matrisome database and the Core SASP.

A) Proteins identified from wild-type mouse femurs were compared to components of the core matrisome showing most representation to least representation as follows: Collagens (24 proteins), glycoproteins (71 proteins), proteoglycans (19 proteins), ECM affiliated proteins (24 proteins), ECM regulators (70 proteins), secreted proteins (22 proteins) [64–66]. B) Additional comparisons of the bone proteome to the Core SASP show 131 overlapping protein identifications and only 19 unique core SASP proteins [25].