Time-course of WD effects on plasma markers of liver injury.

Plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in female [A] and male [B] Ldlr-/- mice. Plasma levels of ALT and AST were measured as described in Methods. Statistical differences (p<0.05) between LFD and WD fed mice after 40 wks on the WD are designated by an asterisk (ӿ).