Allele frequency changes across centuries reveal candidates for positive selection.

(A) Allele frequency change for approximately 5 kb genomic windows, focusing on the 1800s–1933 time interval (scan A), as quantified by PBE. Genes within top outlier regions that are discussed in the text are indicated. (B) PBE is shown for the same genomic windows, focused on the 1933–2010s time interval (scan B). (C) Window-level PBE is shown for a roughly 50 kb region focusing on the top outlier region from scan A, with the position of the known selection target ChKov1 indicated. (D) Window-level PBE is shown for a roughly 100 kb region focusing on the top outlier region from scan B, with the position of the known selection target Cyp6g1 indicated. Data underlying this figure can be found in S8 Table.