Each row shows the LOH of one microsatellite marker on Chr18, and each column shows the data for one intestinal tumor. Open circles indicate the loss of either the wild-type or Min alleles, and filled circles indicate the retention of both alleles. Based on the LOH results, each tumor was categorized as 0 Gy Unidentified, 2 Gy Unidentified, or 2 Gy Deletion. (TIF)</p
Loss of heterozygosity (LOH) occurs commonly in some human tumors and is thought to reflect the sele...
Loss of heterozygosity (LOH) on 8p occurs at high frequencies in many tumor types, including colorec...
<p>(A) Schematic illustration of the chr. 18 LOH event in intestinal tumors from <i>in cis Apc</i><s...
The results for Chr18 are shown for each tumor type. The Tumor ID is shown above each depicted Chr18...
Quantitative PCR was performed using Gapdh as an internal control. Each point represents Apc mRNA le...
BACKGROUND & AIMS: Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndromes I and ...
Microsatellite marker positions are referenced to the NCBI37/mm9 mouse genome sequence. (XLSX)</p
The aim of elimination test (Et) is to identify tumor antagonizing genes from chromosome regions tha...
Quantitative PCR was performed using Gapdh as an endogenous control. Each point represents Apc mRNA ...
Sequence analysis of Apc in intestinal tumors from B6/B6-Chr18MSM-F1 ApcMin/+ mice.</p
The Min mouse, generated by random germline mutagenesis, carries a mutation in the mouse homolog of ...
An experimental system, called the elimination test (Et), was developed to identify tumor growth ant...
<p>(A) immunoblot analysis of isolated IECs indicating efficient deletion of A20 from the small bowe...
<p>(A) Representative phosphor images showing LOH for the markers D8S1819, D8S277 and D8S1798 flanki...
Microsatellite instability (MSI) is caused by DNA mismatch repair deficiency and is an important pro...
Loss of heterozygosity (LOH) occurs commonly in some human tumors and is thought to reflect the sele...
Loss of heterozygosity (LOH) on 8p occurs at high frequencies in many tumor types, including colorec...
<p>(A) Schematic illustration of the chr. 18 LOH event in intestinal tumors from <i>in cis Apc</i><s...
The results for Chr18 are shown for each tumor type. The Tumor ID is shown above each depicted Chr18...
Quantitative PCR was performed using Gapdh as an internal control. Each point represents Apc mRNA le...
BACKGROUND & AIMS: Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndromes I and ...
Microsatellite marker positions are referenced to the NCBI37/mm9 mouse genome sequence. (XLSX)</p
The aim of elimination test (Et) is to identify tumor antagonizing genes from chromosome regions tha...
Quantitative PCR was performed using Gapdh as an endogenous control. Each point represents Apc mRNA ...
Sequence analysis of Apc in intestinal tumors from B6/B6-Chr18MSM-F1 ApcMin/+ mice.</p
The Min mouse, generated by random germline mutagenesis, carries a mutation in the mouse homolog of ...
An experimental system, called the elimination test (Et), was developed to identify tumor growth ant...
<p>(A) immunoblot analysis of isolated IECs indicating efficient deletion of A20 from the small bowe...
<p>(A) Representative phosphor images showing LOH for the markers D8S1819, D8S277 and D8S1798 flanki...
Microsatellite instability (MSI) is caused by DNA mismatch repair deficiency and is an important pro...
Loss of heterozygosity (LOH) occurs commonly in some human tumors and is thought to reflect the sele...
Loss of heterozygosity (LOH) on 8p occurs at high frequencies in many tumor types, including colorec...
<p>(A) Schematic illustration of the chr. 18 LOH event in intestinal tumors from <i>in cis Apc</i><s...