(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ- and the ε-types are identical to those shown in Fig 1C. Data points are shown as mean ± sem. (A2), (B2), IC50s of chimeric subunits. Points and bars indicate IC50 of individual oocytes and the means, respectively. Error bars indicate SEM. P values are shown above the bars (N = 5 for the δ/ε/ε, N = 6 for the ε/δ/δ).</p
<p>(A) Depiction of a possible arrangement of <i>O. dentatum</i> UNC-29, UNC-63 & UNC-38. ‘X’ repres...
<p>A) Responses to ACh (3 mM on α7 nAChRs and 100 µM on other nAChR subtypes; black bars) and to com...
<p>(A) Diagram of possible subunit arrangements of <i>Ode-unc-29</i> and <i>Ode-unc-63</i>. X repres...
(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ- and the ε-types are identica...
(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ- and the ε-types are identica...
(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ-type and the ε-type are ident...
(A1), (B1), Dose-dependent inhibition of the ε-type (A1) and the δ-type (B1) at 2 or 100 μM ACh. Dat...
(A), Pentameric combination of zebrafish nAChR subunits. (B), Representative current traces of the ε...
Current amplitudes of receptors elicited by 100 μM ACh in the absence of pancuronium. Currents were ...
(A), (B), (C), (D), (E), (F), (G), (H), Dose dependency of ACh currents recorded from oocytes co-inj...
(A), Chemical structures of muscle relaxants. (B1), Representative current traces of the ε-type (upp...
(A), nAChR containing the δ and the ε subunits (left) or two δ subunits (middle) are functional. In ...
<p>(<b>A</b>) α4β2 nAChRs with 3α:2β stoichiometry have three binding sites for ACh (black arrows): ...
<p>Inhibition curves for dihydro-β-erythroidine (DhβE) and methyllycaconitine (MLA) on α7 (filled ci...
A) Configuration of nAChR α4 and β2 protein subunits in each of the two isoforms. In this case, full...
<p>(A) Depiction of a possible arrangement of <i>O. dentatum</i> UNC-29, UNC-63 & UNC-38. ‘X’ repres...
<p>A) Responses to ACh (3 mM on α7 nAChRs and 100 µM on other nAChR subtypes; black bars) and to com...
<p>(A) Diagram of possible subunit arrangements of <i>Ode-unc-29</i> and <i>Ode-unc-63</i>. X repres...
(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ- and the ε-types are identica...
(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ- and the ε-types are identica...
(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ-type and the ε-type are ident...
(A1), (B1), Dose-dependent inhibition of the ε-type (A1) and the δ-type (B1) at 2 or 100 μM ACh. Dat...
(A), Pentameric combination of zebrafish nAChR subunits. (B), Representative current traces of the ε...
Current amplitudes of receptors elicited by 100 μM ACh in the absence of pancuronium. Currents were ...
(A), (B), (C), (D), (E), (F), (G), (H), Dose dependency of ACh currents recorded from oocytes co-inj...
(A), Chemical structures of muscle relaxants. (B1), Representative current traces of the ε-type (upp...
(A), nAChR containing the δ and the ε subunits (left) or two δ subunits (middle) are functional. In ...
<p>(<b>A</b>) α4β2 nAChRs with 3α:2β stoichiometry have three binding sites for ACh (black arrows): ...
<p>Inhibition curves for dihydro-β-erythroidine (DhβE) and methyllycaconitine (MLA) on α7 (filled ci...
A) Configuration of nAChR α4 and β2 protein subunits in each of the two isoforms. In this case, full...
<p>(A) Depiction of a possible arrangement of <i>O. dentatum</i> UNC-29, UNC-63 & UNC-38. ‘X’ repres...
<p>A) Responses to ACh (3 mM on α7 nAChRs and 100 µM on other nAChR subtypes; black bars) and to com...
<p>(A) Diagram of possible subunit arrangements of <i>Ode-unc-29</i> and <i>Ode-unc-63</i>. X repres...