Type I IFN signaling is required for altered naïve CD8 T cell compartment following sepsis.

(A) Experimental design. WT and Ifnar-/- mice underwent sham or CLP surgery, and the expression of Ly6C on naïve CD8 T cells was monitored. Frequency of Ly6C-/+ naïve CD8 T cells in (B) sham and (C) CLP operated Ifnar-/- mice. (D) Number of Ly6C+ naïve CD8 T cells per mL of blood 1 day before and 14 days post-CLP in WT and Ifnar-/- mice. (E) CD8 T cell related marker expression on Ly6C- and Ly6C+ naïve CD8 T cells 20 days post-sham/CLP surgery. Data are representative of at least two independent experiments with at least 5 mice per group. Error bars represent SEM. ****p (EPS)