<i>Htt</i> CAG length correlation with different alternative splicing events’ types in the striatum of KI mouse models.

The bar graphs report the number of different alternative splicing events’ types (A3SS: Alternative 3’ splice site, A5SS: Alternative 5’ splice site, MXE: Mutually exclusive exon, RI: Retained intron and SE: Skipped exon) significantly altered in the striatum of mouse KI models of HD, presenting 6 different Htt CAG repeat lengths (Q20, Q80, Q92, Q111, Q140 and Q175) and 3 time points (2, 6, and 10 months; Blue, Orange and Green, respectively). The inclusion level is calculated in comparison to Q20 controls and the positive or negative values are plotted in the graph. The number of events is reported for each genotype and time point. Source data by Langfelder P. et al (2016) [28]. Further details can be found in the Methods section and S1 Table. The Pearson’s correlation (R2) between different AS events’ types and Htt CAG expansion is plotted in each graph. Standard deviations and trend lines are also presented. (TIFF)