<i>Htt</i> CAG-expansion ESC and NPC express appropriate transcriptional markers.
- Dilara Ayyildiz (17145143)
- Guendalina Bergonzoni (17145146)
- Alan Monziani (17145149)
- Takshashila Tripathi (6495392)
- Jessica Döring (17145152)
- Emanuela Kerschbamer (6495395)
- Francesca Di Leva (269600)
- Elia Pennati (17145155)
- Luisa Donini (17145158)
- Marina Kovalenko (136557)
- Jacopo Zasso (17145161)
- Luciano Conti (59559)
- Vanessa C. Wheeler (8139930)
- Christoph Dieterich (41457)
- Silvano Piazza (114562)
- Erik Dassi (9314405)
- Marta Biagioli (6495398)
Publication date
October 2023
DOIAbstract
The heatmap describes the normalized counts per millions (cpm) of cell types specific markers as described in [38]. Astrocytes, microglia, neurons, oligodendrocytes, neural progenitors and pluripotent cells were analysed for heterozygous Htt CAG knock-in HttQ20, HttQ50, HttQ92 and HttQ111 (Q20, Q50, Q92, Q111) in their transition from ESC to NPC. This deep transcriptional characterization confirms a similar pattern of expression between different genotypes and a still not fully committed neuronal progenitor state. (TIFF)</p
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