Concomitant use of argatroban and warfarin during hemodialysis in heparin-induced thrombocytopenia

AbstractObjective and importanceThe use of argatroban during hemodialysis in a patient receiving warfarin is not established. We present a case of heparin-induced thrombocytopenia in a patient on hemodialytic therapy who successfully received argatroban concomitantly to warfarin during renal replacement therapy.Clinical presentationA 46-year-old male patient with autosomal dominant polycystic kidney disease presented with heparin-induced thrombocytopenia (HIT) arised during dialytic procedures.InterventionAfter the acute episode requiring argatroban and warfarin therapy, the patient continued to receive argatroban during the hemodialytic session concomitantly to warfarin.ConclusionThe administration of argatroban in the dialytic circuit of a patient on oral anticoagulant therapy can be considered an effective and safe approach