Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells
- Alessandro Caraffa
- C. Ciampoli
- D De Amicis
- M.L. Castellani
- C. Orso
- P. Felaco
- Stefano Tetè
- Vincenzo Salini
- Elena Toniato
- Y.B. Shaik
- Giuseppe Sabatino
- Giuliano Giorgio Cerulli
- Paolo Boscolo
- C. Cucurullo
- F. Conti
- Franco Pandolfi
- Pierluigi Antinolfi
- Mario Fulcheri
- Jacopo Vecchiet
DOIAbstract
IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source of IL-32, which has been found to be a powerful pro-inflammatory mediator. Here we studied the effect of IL-32 on histamine release by human-derived cord-blood mast cells. In these studies we found that IL-32 significantly stimulates the release of histamine only at high concentrations (100 ng/ml) while at 10 or 50 ng/ml it had no effect. These results were found for the first time and demonstrate that IL-32 may play an important role in allergic and inflammatory diseases
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