Design and development of a dual-flow bioreactor mimicking intestinal peristalsis and permeability in epithelial tissue barriers for drug transport assessment.

we present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the intestine circulation and rhythmic peristaltic movement. This custom-designed, pulsatile membrane bioreactor, with programmable manipulation, allows adjustment of luminal flow rate. In addition, this system is also capable of achieving the intestine-like drug distribution to the cells by the luminal perfusion of the hollow channel compartment. This dynamic platform can mimic the human intestine with increased accuracy to overcome many of the limitations with the previously described in vitro intestinal models, providing a more representative model of the human intestine