Summary The design of effective, vector-based malaria transmission blocking strategies relies on a thorough understanding of the molecular and cellular interactions that occur during the parasite sporogonic cycle in the mosquito. During Plasmodium berghei invasion, transcription from the SRPN10 locus, encoding four serine protease inhibitors of the ovalbumin family, is strongly induced in the mosquito midgut. Herein we demonstrate that intense induction as well as redistribution of SRPN10 occurs specifically in the parasite-invaded midgut epithelial cells. Quantitative analysis establishes that in response to epithelial invasion, SRPN10 translocates from the nucleus to the cytoplasm and this is followed by strong SRPN10 overexpression....
SummaryAlthough eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three ...
Malaria transmission relies on parasite-mosquito midgut interaction. The interactive proteins are hy...
This article was supported by the German Research Foundation (DFG) and the Open Access Publication F...
The design of effective, vector-based malaria transmission blocking strategies relies on a thorough ...
The genomic locus SRPN10 of the malaria vector Anopheles gambiae codes for four alternatively splice...
Anopheles gambiae is the most prominent vector of human malaria in Africa. The causative agents of t...
Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasi...
SummaryBackground: The malaria parasite Plasmodium must complete a complex developmental life cycle ...
Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasi...
Serpins are central to the modulation of various innate immune responses in insects and are suspecte...
BACKGROUND: Plasmodium parasites need to cross the midgut and salivary gland epithelia to complete t...
AbstractDuring its life cycle the malarial parasite Plasmodium forms three invasive stages which hav...
<div><h3>Background</h3><p><em>Plasmodium</em> parasites need to cross the midgut and salivary gland...
<div><p>Serine proteinase inhibitors of the serpin family are well known as negative regulators of h...
Serpins are the dominant group of protease inhibitors in metazoans that control a wide variety of bi...
SummaryAlthough eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three ...
Malaria transmission relies on parasite-mosquito midgut interaction. The interactive proteins are hy...
This article was supported by the German Research Foundation (DFG) and the Open Access Publication F...
The design of effective, vector-based malaria transmission blocking strategies relies on a thorough ...
The genomic locus SRPN10 of the malaria vector Anopheles gambiae codes for four alternatively splice...
Anopheles gambiae is the most prominent vector of human malaria in Africa. The causative agents of t...
Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasi...
SummaryBackground: The malaria parasite Plasmodium must complete a complex developmental life cycle ...
Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasi...
Serpins are central to the modulation of various innate immune responses in insects and are suspecte...
BACKGROUND: Plasmodium parasites need to cross the midgut and salivary gland epithelia to complete t...
AbstractDuring its life cycle the malarial parasite Plasmodium forms three invasive stages which hav...
<div><h3>Background</h3><p><em>Plasmodium</em> parasites need to cross the midgut and salivary gland...
<div><p>Serine proteinase inhibitors of the serpin family are well known as negative regulators of h...
Serpins are the dominant group of protease inhibitors in metazoans that control a wide variety of bi...
SummaryAlthough eukaryotic protein kinases (ePKs) contribute to many cellular processes, only three ...
Malaria transmission relies on parasite-mosquito midgut interaction. The interactive proteins are hy...
This article was supported by the German Research Foundation (DFG) and the Open Access Publication F...