Whereas the tumor acidic extracellular pH plays a crucial role in the invasive process, the mechanism(s) behind this acidification, especially in low nutrient conditions, are unclear. The regulation of the Na(+)/H(+) exchanger (NHE) and invasion by serum deprivation were studied in a series of breast epithelial cell lines representing progression from non-tumor to highly metastatic cells. Whereas serum deprivation reduced lactate production in all three cells lines, it inhibited NHE activity in the non-tumor cells and stimulated it in the tumor cells with a larger stimulation in the metastatic cells. The stimulation of NHE in the tumor cell lines was the result of an increased affinity of the internal H(+) regulatory site of the NHE without...
To sustain tumor growth, the cancer cells need to adapt to low levels of oxygen (i.e., hypoxia) in t...
Extracellular matrix (ECM) degradation is a critical process in tumor cell invasion and requires mem...
To adjust cell growth and proliferation to changing environmental conditions or developmental requir...
Whereas the tumor acidic extracellular pH plays a crucial role in the invasive process, the mechanis...
Whereas the tumor acidic extracellular pH plays a crucial role in the invasive process, the mechanis...
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microen...
Introduction An increasing body of evidence shows that the tumour microenvironment is essential in d...
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading...
Cancer cells and tissues, regardless of their origin and genetic background, have an aberrant regula...
<p>Precise acid-base homeostasis is essential for maintaining normal cell proliferation and growth. ...
Intrinsic or acquired radioresistance often limits the efficacy of radiation therapy (RT), thereby l...
Metastasis results from a sequence of selective events often involving interactions with elements of...
Dysregulation of Na?/H? exchanger isoform one (NHE1) activity is a hallmark of cells undergoing tumo...
Metastasis results from a sequence of selective events often involving interactions with elements of...
Cancer cells have an unusual regulation of hydrogen ion dynamics that are driven by poor vascularity...
To sustain tumor growth, the cancer cells need to adapt to low levels of oxygen (i.e., hypoxia) in t...
Extracellular matrix (ECM) degradation is a critical process in tumor cell invasion and requires mem...
To adjust cell growth and proliferation to changing environmental conditions or developmental requir...
Whereas the tumor acidic extracellular pH plays a crucial role in the invasive process, the mechanis...
Whereas the tumor acidic extracellular pH plays a crucial role in the invasive process, the mechanis...
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microen...
Introduction An increasing body of evidence shows that the tumour microenvironment is essential in d...
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading...
Cancer cells and tissues, regardless of their origin and genetic background, have an aberrant regula...
<p>Precise acid-base homeostasis is essential for maintaining normal cell proliferation and growth. ...
Intrinsic or acquired radioresistance often limits the efficacy of radiation therapy (RT), thereby l...
Metastasis results from a sequence of selective events often involving interactions with elements of...
Dysregulation of Na?/H? exchanger isoform one (NHE1) activity is a hallmark of cells undergoing tumo...
Metastasis results from a sequence of selective events often involving interactions with elements of...
Cancer cells have an unusual regulation of hydrogen ion dynamics that are driven by poor vascularity...
To sustain tumor growth, the cancer cells need to adapt to low levels of oxygen (i.e., hypoxia) in t...
Extracellular matrix (ECM) degradation is a critical process in tumor cell invasion and requires mem...
To adjust cell growth and proliferation to changing environmental conditions or developmental requir...