Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome: much progress and many remaining issues

There is currently a lot of interest among clinical hematologists for the thrombotic microangiopathies called thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). These diseases are rare – their combined incidence is one annual case per 100,000 people in the genera