Abstract Polyamines have been shown to participate in the rectification of cloned inwardly rectifying potassium channels, a class of potassium channel proteins that conducts inward current more readily than outward current. Here, basophil leukemia cells were used to determine the effects of polyamines on a native, inwardly rectifying potassium current. Rat basophil leukemia cells were cultured in the presence of two different polyamine biosynthesis inhibitors, and both the electrophysiological properties and the polyamine levels were monitored. Treatment with α-difluoromethylornithine, a specific ornithine decarboxylase inhibitor, resulted in no significant change of electrophysiological properties. In contrast, treatment with 5′-{[(Z)-4-am...
Phosphatidylinosital-4,5-bisphosphate (PIP2) acts as an essential factor regulating the activity of ...
AbstractPolyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-d-aspa...
AbstractInwardly rectifying K+ channels conduct more inward than outward current as a result of volt...
Inward rectification in strong inward rectifiers such as Kir2.1 is attributed to voltage-dependent b...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65480/1/jphysiol.2005.097741.pd
Intracellular polyamines are endogenous blockers of inwardly rectifying potassium (Kir) channels and...
Inwardly-rectifying potassium (Kir) channels comprise a transmembrane domain (TMD) that makes up the...
AbstractStrongly inwardly rectifying potassium channels are blocked by intracellular polyamines with...
The polyamines spermine and spermidine are found ubiquitously in all mammalian cells where they play...
AbstractCa2+-permeable glutamate receptors assembled from subunits containing a GLN residue at the R...
Polyamines such as spermidine and spermine are found in nearly all cells, at concentrations ranging ...
AbstractInward rectifier K+ channels mediate the K+ conductance at resting potential in many types o...
AbstractWe report that voltage-gated Na+ channels (NaV) from rat muscle (μ1) expressed in HEK293 cel...
Inward rectifier potassium channels conduct K+ across the cell membrane more efficiently in the inwa...
Potassium conduction through unblocked inwardly rectifying (IRK1, Kir2.1) potassium channels was mea...
Phosphatidylinosital-4,5-bisphosphate (PIP2) acts as an essential factor regulating the activity of ...
AbstractPolyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-d-aspa...
AbstractInwardly rectifying K+ channels conduct more inward than outward current as a result of volt...
Inward rectification in strong inward rectifiers such as Kir2.1 is attributed to voltage-dependent b...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65480/1/jphysiol.2005.097741.pd
Intracellular polyamines are endogenous blockers of inwardly rectifying potassium (Kir) channels and...
Inwardly-rectifying potassium (Kir) channels comprise a transmembrane domain (TMD) that makes up the...
AbstractStrongly inwardly rectifying potassium channels are blocked by intracellular polyamines with...
The polyamines spermine and spermidine are found ubiquitously in all mammalian cells where they play...
AbstractCa2+-permeable glutamate receptors assembled from subunits containing a GLN residue at the R...
Polyamines such as spermidine and spermine are found in nearly all cells, at concentrations ranging ...
AbstractInward rectifier K+ channels mediate the K+ conductance at resting potential in many types o...
AbstractWe report that voltage-gated Na+ channels (NaV) from rat muscle (μ1) expressed in HEK293 cel...
Inward rectifier potassium channels conduct K+ across the cell membrane more efficiently in the inwa...
Potassium conduction through unblocked inwardly rectifying (IRK1, Kir2.1) potassium channels was mea...
Phosphatidylinosital-4,5-bisphosphate (PIP2) acts as an essential factor regulating the activity of ...
AbstractPolyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-d-aspa...
AbstractInwardly rectifying K+ channels conduct more inward than outward current as a result of volt...