Acetyl-cholinesterase Inhibition by Extracts and Isolated Flavones from Linaria reflexa Desf. (Scrophulariaceae):
- Giancarlo Statti
- Rosa Tundis
- Federica Menichini
- Monica Rosa Loizzo
- Peter J. Houghton
- Marco Bonesi
- Brigitte Deguin
- Francesco Menichini
- François Tillequin
DOIAbstract
Extracts, linariin, isolinariin A and B obtained from Linaria reflexa Desf. (Scrophulariaceae) were tested for acetylcholinesterase inhibition activity using Ellman's method. A dose-response relationship was observed for all extracts and isolated compounds. Flavones exhibited IC50 values ranging from 0.27 μM to 0.30 μM. The structure-activity relationship was briefly discussed
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