ATP is released from astrocytes and is involved in the propagation of calcium waves among them. Neuronal ATP secretion is quantal and calcium-dependent, but it has been suggested that ATP release from astrocytes may not be vesicular. Here we report that, besides the described basal ATP release facilitated by exposure to calcium-free medium, astrocytes release purine under conditions of elevated calcium. The evoked release was not affected by the gap-junction blockers anandamide and flufenamic acid, thus excluding purine efflux through connexin hemichannels. Sucrose-gradient analysis revealed that a fraction of ATP is stored in secretory granules, where it is accumulated down an electrochemical proton gradient sensitive to the v-ATPase inhib...
This study investigates the role of glycogenolysis in stimulated release of ATP as a transmitter fro...
none14siBackground information: ATP is the main transmitter stored and released from astrocytes unde...
1. This study was aimed at characterizing ATP-induced rises in cytosolic free calcium ion, [Ca2+](i)...
ATP is released from astrocytes and is involved in the propagation of calcium waves among them. Neur...
ATP is released from astrocytes and is involved in the propagation of calcium waves among them. Neur...
Astrocytes appear to communicate with each other as well as with neurons via ATP. However, the mecha...
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can...
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can...
<div><p>Communication between neuronal and glial cells is important for many brain functions. Astroc...
Astrocytes, the major glial cell type in the CNS, have been considered to be passive bystanders t...
ATP is well established as a transmitter and modulator in the peripheral and central nervous system....
<p>Release of ATP from cortical astrocytes of wild-type (A, B) and dn-SNARE mice (C) was detected us...
<p>Release of ATP from cortical astrocytes of wild-type (A, B) and dn-SNARE mice (C) was detected us...
ATP has been indicated as a primary factor in microglial response to brain injury and inflammation. ...
<p>(A) Astrocytes acutely dissociated from the wild-type mouse neocortex have been loaded with UV-ph...
This study investigates the role of glycogenolysis in stimulated release of ATP as a transmitter fro...
none14siBackground information: ATP is the main transmitter stored and released from astrocytes unde...
1. This study was aimed at characterizing ATP-induced rises in cytosolic free calcium ion, [Ca2+](i)...
ATP is released from astrocytes and is involved in the propagation of calcium waves among them. Neur...
ATP is released from astrocytes and is involved in the propagation of calcium waves among them. Neur...
Astrocytes appear to communicate with each other as well as with neurons via ATP. However, the mecha...
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can...
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can...
<div><p>Communication between neuronal and glial cells is important for many brain functions. Astroc...
Astrocytes, the major glial cell type in the CNS, have been considered to be passive bystanders t...
ATP is well established as a transmitter and modulator in the peripheral and central nervous system....
<p>Release of ATP from cortical astrocytes of wild-type (A, B) and dn-SNARE mice (C) was detected us...
<p>Release of ATP from cortical astrocytes of wild-type (A, B) and dn-SNARE mice (C) was detected us...
ATP has been indicated as a primary factor in microglial response to brain injury and inflammation. ...
<p>(A) Astrocytes acutely dissociated from the wild-type mouse neocortex have been loaded with UV-ph...
This study investigates the role of glycogenolysis in stimulated release of ATP as a transmitter fro...
none14siBackground information: ATP is the main transmitter stored and released from astrocytes unde...
1. This study was aimed at characterizing ATP-induced rises in cytosolic free calcium ion, [Ca2+](i)...